Clemons played on such classic hits as "Born to Run" and "Thunder Road" and is widely credited with helping to shape Springsteen's sound.
He passed away at a hospital in Palm Beach, Florida, where he had stayed ever since suffering a stroke last Sunday, said a spokesperson for Springsteen and the E Street Band. He was surrounded by members of his family, including his wife, Victoria, according to the spokesperson.
Standing at more than 6 feet tall, Clemons was affectionately known as the "Big Man" to fans. He published his autobiography "Big Man: Real Life & Tall Tales" in 2009 and suffered some health problems in recent years.
In addition to his career as a musician, Clemons also worked as an actor, appearing in the TV shows "The Wire" and "The Simpsons" as well as the films "Bill & Ted's Excellent Adventure" and "New York, New York."
Clemons was 69 years old. Link to obituary. Link to a video tribute.