That's the highest denomination dollar bill ever printed. Well, actually it's a not a dollar bill, it's a gold certificate:
What's a gold certificate? Well a gold certificate is money that the government prints that only they can own and use. It is intended for only the use in Fiscal Channels. They were never issued or used for general circulation. This specific gold certificate was printed in 1934 and has the 28th president, Woodrow Wilson's portrait on it. There were only 42,000 $100,000 dollar bills printed and the only ones around today are not for sale and are used for educational purposes only. The few remaining undestroyed $100,000 bills are institutionalized today and may be seen only in some museums.
More at the fascinating The Biggest Dollar Bills in United States History article at Purple Slinky blog : Link - Thanks Jon Jason!