The khene is an instrument used by some ethnic groups that live in the highlands of Thailand, Cambodia, and Laos. It's a reedless mouth organ, so the khene is in the same instrument family as the harmonica.
Pat Fernandez of Pat's Soundhouse is a multi-instrumental musician whose skills include the use of the khene. He begins this original composition for the khene with honks that sound exactly like a car alarm. He then transitions into a melodious song that surrounds the car alarm beat.
-via Laughing Squid