Prozac: No Better Than Placebo?

By Alex in Health on Feb 27, 2008 at 3:41 am

Some 40 million people worldwide take the antidepressant drug Prozac. But according to a new study, it’s actually no better than placebo.

What’s even more damning is that the scientists got the data from studies that the pharmaceutical companies chose not to publish, through the Freedom of Information Act:

The review breaks new ground because Kirsch and his colleagues have obtained for the first time what they believe is a full set of trial data for four antidepressants.

They requested the full data under freedom of information rules from the Food and Drug Administration, which licenses medicines in the US and requires all data when it makes a decision.

The pattern they saw from the trial results of fluoxetine (Prozac), paroxetine (Seroxat), venlafaxine (Effexor) and nefazodone (Serzone) was consistent. "Using complete data sets (including unpublished data) and a substantially larger data set of this type than has been previously reported, we find the overall effect of new-generation antidepressant medication is below recommended criteria for clinical significance," they write.

Link – via Blue’s News

Regardless of whether Prozac works for humans, it seems that it works very well for parrots: Owners Give Prozac to Depressed Pets – via Look at This


Email This Post
Tweet This Post 
Share This Post on Facebook


Neat stuff from the NeatoShop:


  1. Edward
    Feb 27th, 2008 at 4:47 am

    When “science” does not match human experience, we need to question the study, not ourselves. Monoamine Oxidase Inhibitors have improved the lives of many families.

    Without access to the raw data, I cannot comment on specifics. My prediction is that this study combined results from multiple trials that should not have been grouped together.

  2. Matt
    Feb 27th, 2008 at 4:48 am

    This has been widely misreported. The study results are slightly more subtle:
    http://www.badscience.net/?p=619

    (I’m no expert, I just happened to read the above article before coming here)

  3. Edward
    Feb 27th, 2008 at 4:56 am

    Please allow me to correct an error in my previous post. While MAOIs are antidepressants as are SSRIs, fluoxetine hydrochloride (Prozac) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.

  4. ted
    Feb 27th, 2008 at 6:26 am

    Thanks for clearing that up. I was just wondering whether fluoxetine hydrochlorine (Prozac) was an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class or not.

  5. MoonCake
    Feb 27th, 2008 at 7:36 am

    moral of the story: don’t trust the FDA.

    they’ll approve anything to make a buck. pharmaceuticals (sp?) are so dangerous anyway; they’re turning us into chemical-dependent robots. they would rather see us spend money on a drug with numerous side-effects than recommend a form of hollistic or preventative care. on commercials you’ll hear them say “this product has been approved by the FDA” which really only means they reviewed the product and get a cut of the profit.

    they’re the ones who allow antibiotics and growth hormones to be injected into our meat. they’re the ones that recalled all those drugs after approving them. they’re the ones that shot my ma! well, not literally, but it could be tied to the incident.. my step-father was at an unusual part in his life and he was prescribed lexipro, an anti-depressant. it apparently wasn’t helping his case, so they took him off of it. a week later, he killed my mom and himself. i do know that lexipro has been known to cause suicidal tendencies (yet it remains available on the market). i also know that these tendencies are enhanced when the person is taken off the medicine abruptly. whether or not i can attribute lexipro’s unknown side-effects to my mother’s death will never be known, but it’s the closest to an answer i can get through deductive reasoning, and i don’t have enough evidence to sue. SO moral of the story: don’t trust the FDA. :)

  6. Lo
    Feb 27th, 2008 at 8:32 am

    I don’t think it’s a placebo. If it didn’t interact with your brain at all it wouldn’t have screwed me up more than I already was before I started taking it. :/ At the time I was 15 and “obviously didn’t know what I was talking about” and the morons wouldn’t help me find one that WOULD work for me.

  7. Tempscire
    Feb 27th, 2008 at 8:39 am

    *stage whisper* Pssst, MoonCake, humans are already chemically-dependent. These are just artificially-introduced/made. ;)

  8. aerio
    Feb 27th, 2008 at 12:48 pm

    “Monoamine Oxidase Inhibitors have improved the lives of many families.”

    And they’ve done the opposite. Google prozac and suicide.

  9. Dan
    Feb 27th, 2008 at 1:28 pm

    Prozac may be no better, but a placebo never turned it’s victim into either a brain-dead idiot or a psychotic killer…

    http://www.google.com/search?q=prozac+suicide
    252,000 reusults

    http://www.google.com/search?q=prozac+murder
    639,000 results

  10. RSMilward
    Feb 27th, 2008 at 7:29 pm

    I prefer generic Placebo to brand-name Placebo because I find it to be just as effective… :-)

  11. Terry
    Feb 28th, 2008 at 12:05 am

    It’s hard not to laugh at the people that take antidepressants and say they work.

  12. Jimbo
    Feb 28th, 2008 at 6:06 am

    Psychiatry: Never has cured ANYONE! It is a total scam

    http://www.youtube.com/watch?v=S6Q4dMy5aF8

  13. Kathe
    May 25th, 2008 at 11:22 pm

    While a fascinating study, I know firsthand that psychiatric medications are better then a placebo. I have severe bipolar disorder, and the difference between when I am on my meds and off my meds is staggering.

  14. Susan
    Jun 29th, 2009 at 7:02 am

    > I know firsthand that psychiatric medications are
    > better then a placebo. I have severe bipolar
    > disorder, and the difference between when I am on
    > my meds and off my meds is staggering.

    That’s what a placebo does. It makes you THINK you are being helped a great deal…. when it’s actually doing nothing really.


Keep track of the comments with Comment RSS

Don't Miss: New Stuff | Bestsellers | The Cute Store
                   Funny T-Shirts

Need a gift? Get unforgettable gifts for:
Geeks | Pranksters | Kids | Hipsters | Shutterbugs

Lijit Search

Old school? Bookmark us! RSS Feed Twitter Facebook Page