Begging the question. Without definitions, such things are mere conversation fodder. For example, to mere mortals: tone, shade, and color mean the same thing. To a trained designer, they are very different.
A great novel could be written about the individuals who personally fought disease. Pasture, Jenner, Salk, the guy who made doctors wash their hands. Wish I could write. Miss C,. maybe?
The article is over two years old and has no information beyond: problems with the crew before the start, someone got injured, someone else pulled out for safety reasons. A cursory search of the internet shows not much more information. I guess we are to infer that the safety reports were so sever that all future missions were canceled. The organizational investigation will likely never see the light of day.
“This side up” is worthless. If you see that, you are good to go. If you do not, it is upside down but you will not know it. “This side down” is much more useful.
Humans can react to stimuli before baton processing. Touch a hot surface accidentally and you will recoil before feeling pain. Same for putrid smells and some loud noises.
Used in this 1960s TV show.
https://www.imdb.com/title/tt0054521/plotsummary?ref_=tt_ov_pl
https://smile.amazon.com/s?k=waterproof+mouse+and+keyboard&ref=nb_sb_noss_1