Absolutely. I was actually told in an interview that my resume stood out from all the others and he knew he would invite me in for an interview before he had even read it. I think it also varys for the type of position you are applying for. In my world, graphic design, a crappy looking resume probably means you're a crappy designer. I've designed resumes for many friends and relatives who have all had positive feedback from potential employers. Your resume is truly your first impression. If it's boring and bland and blends into the grayness of all the other applicants than it is hard to stand out.