Most of us who grew up since the 1960s (or who had a kid who did) remember the stories of Clifford the Big Red Dog. But one thing overlooked in the books was how his owners could possibly clean up after a dog the size of a house. One recent Reddit thread explored this concept and surprisingly, one Redditor actually came up with a completely reasonable solution: essentially, Clifford's owners would have to rent a commercial-sized dumpster and train the dog to go to the bathroom in it. The cost of cleanup would come out to around $100 a day, but as he points out, that's probably nothing compared to the cost of food for a pooch that big.
You can read the whole thread and more details on taking care of Clifford's business over at Reddit.