New Zealand designers at Unit Seven created a map of "Brainland," which used a digitized photo of a real human brain:
The above map's original data was created from a reference photo of a real human brain which was used to build the 3d terrain. This digital elevation model was then used to create contour line data, relief shading and to plan where the roads and features should be placed for map compilation. Real New Zealand public domain data was then added for the surrounding islands.
Link - via Boing Boing