I have a permanent case of "prune hands." It's caused by a neuro-immune disorder. Immune activation produces elastase and MMP-9, the former of which breaks down elastin (which is what gives skin its elastic quality) and the latter of which breaks down collagen. It actually makes it quite uncomfortable to use a trackpad! My fingerprints are also noticeably smoother than they used to be - my fingerprint scanner on my laptop no longer picks them up, and it did when I bought it in 2007.