Pizzerias are the first eateries I look for while on vacation, because any American city that doesn't have a decent pizza shop simply isn't worth visiting, let alone mentioning.
Thankfully just about every major city in America contains a decent pizza joint or two, so the vacationing can continue!
Roberta's in Brooklyn is literally a hole in the wall joint that serves up some super delicious Neapolitan-style pizza pies cooked in a wood oven:
Start with the mighty Speckenwolf (a dreamy concoction of mushrooms, house-made mozzarella, and marvelously salty slices of speck) and the seasonal Bee Sting (airy, just-crisp-enough crust piled with mozzarella, thin slices of soppressata, tomato sauce, chili flakes, and honey).
If you're on the other side of the country then you've gotta pay a visit to East Hollywood's DeSano Pizza Bakery, where the pizzas are cooked in a wood oven and the ingredients are imported straight from Italy:
The tomato sauce shines here; it’s always made from San Marzano tomatoes, meaning that the pizza at DeSano can be classified as true Neapolitan pizza -- just ask the Associazione Vera Pizza Napoletana. Throw draft beer and authentic Italian gelato in the mix, and it's easy to see why a night at DeSano is a night well-spent.
And slightly to the right of the middle of America is where Chicago can be found, a city known for its deliciously thick deep dish pizzas, and according to most Pequod's Pizza serves up the best pizza in Chi-Town:
Famous for its caramelized crust -- a rich ring of blackened mozzarella that encircles these Chicago cast-iron deep-dish delicacies -- this neighborhood hang sports a more authentic vibe than most of the deep-dish establishments that pull in Downtown tourists. These glorious pizza bombs rock a flaky, almost buttery crust, and once they’re loaded with sausage and/or pepperoni, you'll need a team of eaters to make a run at it.
See The Must-Visit Pizzeria In America's 35 Biggest Cities here