I know that Cracked has a reputation of exaggerating theories as though they are all truth, but they do try to maintain a nugget of truth. To that end, this article about the founding of America and the many lies we've been taught about it are all pretty fascinating.
In the decades between Columbus' discovery of America and the Mayflower landing at Plymouth Rock, the most devastating plague in human history raced up the East Coast of America. Just two years before the pilgrims started the tape recorder on New England's written history, the plague wiped out about 96 percent of the Indians in Massachusetts.
If that is true, it certainly explains a lot. In fact, many of their other list items in the article fit in with this idea.