"Fat Enzyme" Explains Why Some People Never Get Fat

Posted by Alex in Medicine on March 15, 2009 at 4:08 pm


Ever wonder why some people can eat anything they want and never gain weight? UCSF (my alma mater!) researcher Robert Farese and colleagues have found that it may just be the absence of a "fat enzyme":

The enzyme, MGAT2, determines whether dietary fat is used to generate energy or stored under the skin around the waist. The discovery of its role could be the key to preventing obesity, diabetes and heart disease

Scientists found that mice missing the gene for MGAT2 were able to feast on a high fat diet without becoming flabby or overweight.

Mice lacking MGAT2 were also protected against glucose intolerance – a precursor to diabetes – high cholesterol and a build up of fat in liver cells.

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7 comments to ""Fat Enzyme" Explains Why Some People Never Get Fat"

  1. Jim R Feliciano
    March 15th, 2009 at 6:03 pm

    What about all the other aspects of nutrition. If you are missing this enzyme then what else is not happening? I wonder little thing is missing when the enzyme is missing.

  2. Jett
    March 15th, 2009 at 9:57 pm

    I need me to get some of that MGAT2.

  3. just a guy
    March 16th, 2009 at 4:14 am

    sign me up!

  4. Scooter
    March 16th, 2009 at 2:52 pm

    what, Jett don't you want to get ride of it if you have it? or are you a skinny person who can't gain wieght?

  5. Dr. Charles Martin
    March 16th, 2009 at 3:50 pm

    Great post about some promising research. Let's hope this can quickly be translated into something that will help slow the type 2 diabetes epidemic that is raging across the U.S. and much of the developed world. We write about related issues at http://dentistryfordiabetics.com/blog.

    - Charles Martin, DDS
    Founder, Dentistry For Diabetics

  6. Daisy
    March 16th, 2009 at 5:29 pm

    Talking about dentistry. If I had not had my teeth fucked up by the various dentist's I would be able eat better.

    Now all my food is pureed and I have nerve damage in my face and in constant pain all down to the damn dentist.

  7. Gauldar
    March 16th, 2009 at 8:01 pm

    @Daisy

    You can't blame all dentist's for the incompetance of a few.


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