More Than Fine has this Top 5 Viral Videos that Changed Someone's Life (For the Worse).
For example:
5) Gray Brolsma's "Numa Numa" - Gary Brolsma was just a normal kid who knew how to get down with a webcam. But in late 2004, he submitted his "Numa Numa Dance" to Newsgrounds, in which he lip-synched a Romanian song, "Dragostea Din Tei" ("From the Linden Trees")
The world was never the same. Brolsma rocketed to internet stardom nearly overnight, and his video was seen by millions all across the world. His video was seen on CNN and VH1 and Brolsma himself even made an appearance on "Good Morning America"
But apparently, Brolsma wasn't the same again either. In interviews given for a New York Times article from 2005, family and friends described him as moping around the house, feeling himself a victim of his own fame. Apparently, getting recognized on the bus for being that guy that can dance flailingly and move his eyebrows with great force wasn't a big boost for Gary's self-esteem. "I don't know what's wrong with him," his grandfather was quoted as saying.
Link - via GorillaMask