This hole in the sky is now known to astronomers as a dark molecular cloud [wiki]. From Astronomy Picture of the Day:
Here, a high concentration of dust and molecular gas absorb practically all the visible light emitted from background stars. The eerily dark surroundings help make the interiors of molecular clouds some of the coldest and most isolated places in the universe. One of the most notable of these dark absorption nebulae is a cloud toward the constellation Ophiuchus known as Barnard 68, pictured above. That no stars are visible in the center indicates that Barnard 68 is relatively nearby, with measurements placing it about 500 light-years away and half a light-year across. It is not known exactly how molecular clouds like Barnard 68 form, but it is known that these clouds are themselves likely places for new stars to form. It is possible to look right through the cloud in infrared light.