Clark’s Liquid Breathing Mouse.

By Alex in Science & Tech on Feb 20, 2006 at 2:03 am

Dr. Leland Clark, inventor of the platinum "Clark electrodes" used to detect oxygen in liquid (and allows measurement of blood oxygen levels) also did this famous experiment in "liquid breathing":

Dr. Leland Clark of Cincinnati invented a blood substitute allowing this living mouse to breathe in the liquid, while goldfish inhabit the water floating on top.

After bubbling oxygen through the fluorocarbon, the oxygenated fluid was pumped into the animals’ lungs, and recirculated (about 6 cycles of inhalation and exhalation per minute). Most of the animals who were kept in the fluid for up to an hour survived for several weeks after their removal, before eventually succumbing to pulmonary damage.

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  1. John Anderson
    Feb 20th, 2006 at 7:44 am

    Pulmonary damage: too bad. But if improved, useful as G-force protection in spaceflight – excet for cost of lifting it out of a gravity well.

  2. John Anderson
    Feb 20th, 2006 at 7:46 am

    Oh, and in medicine – vast improvement on the water bed (trivia: Robert Heinlein designed what may have been the first while in hospital before being discharged).

  3. iblees
    Feb 20th, 2006 at 9:11 am

    breathing liquid and half dead? what good? what a creative crap.

  4. send me a death threat
    Feb 20th, 2006 at 2:09 pm

    What horror is done in the name of science, almost as bad as religion.

  5. Alex
    Feb 21st, 2006 at 2:39 am

    This was done in the 1960s – I think the idea is to create artificial blood, not development of liquid breathing. :)

  6. Alan
    Feb 23rd, 2006 at 1:50 am

    This also has applications for deep sea diving, research has been going on for some years, not everything in “The Abyss” was fiction.

  7. ann
    Apr 10th, 2006 at 10:44 pm

    mouse murderer wats with scientists they think they are helping but there not

  8. ann
    Apr 10th, 2006 at 10:44 pm

    mouse murderer wats up with those scientists they think they are helping but there not

  9. Slacs
    Mar 25th, 2010 at 12:10 pm

    1st of all, sick and wrong, second of all, that is a poor rat, not a mouse. Do scientists not even know which species they are torturing?

  10. GetOverYourself!
    Dec 8th, 2010 at 1:57 pm

    We all die anyway.

    And they were not causing the rat any pain.

    Don’t refute brilliant experiments done in the name of science simply because you have the means to, please.


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